So what should happen should the male patient undergoing treatment get his female partner pregnant? This happened to a patient of a colleague of mine. They referred the couple to high risk OB/Gyn. I was concerned over the chemotherapy affecting the quality of the sperm and placing the fetus at rick of birth defects. I know this is the case with drugs like Revlimid and Thalomid. But what about other chemo drugs affecting the quality of sperm? I thought my group should be more informed on this topic and be able to advise them more. Thanks in advance for your input.